Archive for category Schizophrenic Patients
How Drugs for Schizophrenia Sow Seeds of Resistance
Posted by psychieblogger in Atypical Antipsychotic Drugs, Brain Area, Chemical Changes, Chronic Administration, Chronic Treatment, Clozapine, Cognition And Perception, Detrimental Effect, Drug Resistance, Genetic Reasons, Groundbreaking Study, Health-related, Javier Gonzalez, Journal Nature Neuroscience, Medicine Report, Mount Sinai School, Mount Sinai School Of Medicine, Mouse Models, Psychology, Psychotic Symptoms, Research, Schizophrenia, Schizophrenic Patients, Technology, Therapeutic Effects, Treating Schizophrenia, Treatment Resistance on August 14, 2012
A new study has identified why certain drugs have mixed success in treating schizophrenia; effective at first, but with chronic administration becoming less and less so.
In the study, reported online in the journal Nature Neuroscience, scientists investigated the external genetic reasons (called epigenetic factors) that cause treatment-resistance to atypical antipsychotic drugs.
Use of antipsychotic drugs is the standard of care for schizophrenia. Researchers at Mount Sinai School of Medicine report that 30 percent of individuals with schizophrenia do not respond to currently available treatments.
Researchers discovered that, over time, an enzyme in the brains of schizophrenic patients, analyzed at autopsy, begins to compensate for the prolonged chemical changes caused by antipsychotics, resulting in reduced efficacy of the drugs.
“These results are groundbreaking because they show that drug resistance may be caused by the very medications prescribed to treat schizophrenia, when administered chronically,” said Javier Gonzalez-Maeso, Ph.D., lead investigator on the study.
Researchers found that an enzyme called HDAC2 was highly expressed in the brain of mice chronically treated with antipsychotic drugs, resulting in lower expression of the receptor called mGlu2 and a recurrence of psychotic symptoms. A similar finding was observed in the postmortem brains of schizophrenic patients.
In response, the research team administered a chemical called suberoylanilide hydroxamic acid (SAHA), which inhibits the entire family of HDACs. This treatment prevented the detrimental effect of the antipsychotic called clozapine on mGlu2 expression, and also improved the therapeutic effects of atypical antipsychotics in mouse models.
Previous research conducted by the team showed that chronic treatment with the antipsychotic clozapine causes repression of mGlu2 expression in the frontal cortex of mice, a brain area key to cognition and perception.
The researchers hypothesized that this effect of clozapine on mGlu2 may play a crucial role in restraining the therapeutic effects of antipsychotic drugs.
“We had previously found that chronic antipsychotic drug administration causes biochemical changes in the brain that may limit the therapeutic effects of these drugs,”said Gonzalez-Maeso. “We wanted to identify the molecular mechanism responsible for this biochemical change, and explore it as a new target for new drugs that enhance the therapeutic efficacy of antipsychotic drugs.”
Mitsumasa Kurita, Ph.D., a postdoctoral fellow at Mount Sinai and the lead author of the study, said, “We found that atypical antipsychotic drugs trigger an increase of HDAC2 in the frontal cortex of individuals with schizophrenia, which then reduces the presence of mGlu2, and thereby limits the efficacy of these drugs.”
As a result of these findings, Gonzalez-Maeso’s team is now developing compounds that specifically inhibit HDAC2 as adjunctive treatments to antipsychotics.
Source:The Mount Sinai Hospital/Mount Sinai School of Medicine
Advocacy and Policy, Atypical Antipsychotics, Brain and Behavior, Dissociation, Frontal Cortex, Genetics, LifeHelper, Medications, Memory and Perception, Mental Health and Wellness, Neuropsychology and Neurology, Personality, Professional
Face in the Mirror More Distorted in Schizophrenia
Posted by psychieblogger in Research, Schizophrenia, Schizophrenia Patients, Schizophrenic Patients, Strange Face, University Of Milan, Zago on August 12, 2012
Individuals with schizophrenia experience more intense perceptual illusions while gazing into a mirror than do healthy people, according to a new study.
The new research also showed that patients with schizophrenia were more likely to believe the illusions they see in the mirror were real.
The research highlights the underlying ego dysfunction and body dysmorphic disorder found in schizophrenia.
According to the researchers, gazing at one’s own reflected face under low light can lead to ghostly experiences called “strange-face in the mirror” illusions. No study has previously focused on mirror gazing in schizophrenic patients, who already experience delirium, hallucination and self mis-attribution.
Stefano Zago of the University of Milan conducted the study to compare strange-face apparitions in response to mirror gazing in 16 patients with schizophrenia and 21 mentally healthy controls.
Subjects took a 7-minute mirror-gazing test, after which they filled out a specially designed questionnaire asking them to describe their strange-face perceptions.
The results show a number of differences between patients with schizophrenia and mentally healthy controls. Patients on average reported a greater total number of strange faces than controls, at 2.8 versus 1.5.
The types of strange faces also differed between patients and controls. Hugely deformed features were seen by all schizophrenia patients and 71% of controls, archetypal faces by 50% of patients and 19% of controls, and monstrous faces by 88% of patients and 29% of controls. Patients’ archetypical and monster faces were typically described as satanic beings.
Furthermore, patients tended to report greater intensity in the strange faces and were more likely to say that they felt real than controls.
Of note, mentally healthy participants felt dissociative experiences during the strange-face illusions and never identified with them.
Overall, the research suggests that strange-face illusions in schizophrenia can be caused by ego dysfunction, body dysmorphic disorder, or by misattribution of self-agency, said Zago.
The research is published in Schizophrenia Research.
Source: Schizophrenia Research
Apparitions, Archetypical, Brain and Behavior, Cognition, Delirium, Dissociation, Dissociative Experiences, Ego, Face In The Mirror, Featured, General, Hallucination, Intensity, Memory and Perception, Monster Faces, Participants, Perceptions, Perceptual Illusions, Questionnaire, Schizophrenia Research
-
You are currently browsing the archives for the Schizophrenic Patients category.
find out…
In the cloud….
Abuse achievement Addiction Adolescence Advocacy and Policy Aging Alcoholism American Psychological Association Anxiety Biological Psychiatry Brain and Behavior Canada care Cognition Compact Disc Current Dialectical behavior therapy Doctor of Psychology Education Emotion Exercise/Fitness Featured Feeling Feelings Gender General Genetics health Investigators Job Journal of Neuroscience Journal Reference LifeHelper love Magnetic resonance imaging Major Depression Marriage Medical News Today Medications Memory and Perception mental-health Mental Health and Wellness mental psych mind Mindfulness MRI Neuropsychology and Neurology Occupation odds Ohio State University PA Pain Parenting Parents partner People Personality Personality and Social Psychology Review Personality development Pharmacology Professional PsychCentral Psychological Science Psychotherapy PTSD Relationship Relationships Relationships and Sexuality Researcher Risk Factor self help Society for Personality and Social Psychology Story Source Stress Response United Statestype of post….
- 3 Fatty Acids (1)
- Abstract Thinking (1)
- ADHD (4)
- Admiration (1)
- Affective Neuroscience (20)
- Albert Einstein (1)
- Albert Einstein College (1)
- Albert Einstein College Of Medicine (1)
- Allure (1)
- Alphas (1)
- American Chemical Society (1)
- American Psychological Association (3)
- Antisocial Behavior (1)
- Antiviral Properties (1)
- Apparent Differences (1)
- Appearance (1)
- Atypical Antipsychotic Drugs (1)
- Autism Research (1)
- Balanced Diet (1)
- Beha (1)
- Behavior Traits (1)
- Behavioral Therapy (1)
- Benefactor (1)
- Benefit From (1)
- Beth Cohen (1)
- Bipolar (1)
- Bipolar Patients (1)
- Bobby Thomas (1)
- Body Chemistry (1)
- Boston Children (1)
- Brad Bushman (1)
- Brain Area (1)
- Brain Bank (1)
- Brain Changes (1)
- Brain Connections (1)
- Brain Health (1)
- Brain Mass (1)
- Brain Synapses (1)
- Brian Wansink (1)
- California State University (1)
- Calorie Counting (1)
- Canada (1)
- Canadian Forces (1)
- Candy Bar (1)
- Carnegie Mellon University (1)
- Carnevale (1)
- Cell Cultures (1)
- Centers For Disease Control (1)
- Centers For Disease Control And Prevention (1)
- Chemical Changes (1)
- Chemical Compounds (2)
- Chemistry Institute (1)
- Children and Teens (14)
- Children With Autism (1)
- Chocolate Blueberries (1)
- Chronic Administration (1)
- Chronic Treatment (1)
- Clout (1)
- Clozapine (1)
- Cocoa Drink (1)
- Cocoa Flavanols (1)
- Cocoa Plants (1)
- Cocoa Products (1)
- Cognition And Perception (1)
- Cognitive Health (1)
- Cognitive Impairment (1)
- Cognitive Tests (1)
- College Age Men (1)
- College Age Students (1)
- College Age Women (1)
- Common Cold Virus (1)
- Common Foods (1)
- Conjunctivitis (1)
- Construal (1)
- Control Experts (1)
- Control Self (1)
- Cornell University (1)
- Coxsackieviruses (1)
- Dan Ariely (1)
- David Creswell (1)
- Davis Researchers (1)
- Deborah Serani (1)
- Defective Gene (1)
- Depakene (1)
- Depressed Patients (1)
- Depression (21)
- Derek Neal (1)
- Detrimental Consequences (1)
- Detrimental Effect (2)
- Dialectical behavior therapy (10)
- Diet Exercise (1)
- Dietary Recommendations (1)
- Disease Control And Prevention (1)
- Dna Damage (1)
- Doctor of Psychology (18)
- Dominic Holland (1)
- Donations (1)
- Drug Molecules (1)
- Drug Resistance (1)
- Duke University (1)
- Duman (1)
- Education (7)
- Einstein College Of Medicine (1)
- Elisabeth Haug (1)
- Emotion (27)
- Energy Use (1)
- Enterovirus Infections (1)
- Environmental Factors (1)
- Expressive Writing (1)
- Family (6)
- Feeling (7)
- Finding Love Again (1)
- Flavor Components (1)
- Florida State University (1)
- Fluoxetine (1)
- Focus Group (1)
- Food Environments (1)
- Foods And Beverages (1)
- Frank Discussions (1)
- Free Radicals (1)
- Fujita (1)
- Fundraiser (1)
- Fundraisers (1)
- Fundraising Goals (1)
- Garry Chick (1)
- Gene Activation (1)
- Gene Change (1)
- Gene Defect (1)
- Genetic Reasons (1)
- Genetic Switch (1)
- Genetic Variety (1)
- Good Nutrition (1)
- Groundbreaking Study (1)
- Group Conversations (1)
- Harvard Medical School (2)
- Health Study (1)
- Health-related (41)
- Healthful Choices (1)
- Hedonism (1)
- High Throughput Screening (1)
- Highest Education (1)
- Hillside Hospital (1)
- History Of Marijuana (1)
- Hourly Rate (1)
- Immediate Gratification (1)
- Incentives (1)
- India (1)
- Influence Individuals (1)
- Insulin Resistance (1)
- Jane Dutton (1)
- Javier Gonzalez (1)
- Jean Twenge (1)
- John Fletcher (1)
- Journal Entries (1)
- Journal Hypertension (1)
- Journal Nature Neuroscience (1)
- Journal Of Personality (1)
- Journal Of Personality And Social Psychology (1)
- Kansas State University (2)
- Laboratory Tests (1)
- Lack Of Time (1)
- Litter Mates (1)
- Long Island Ny (1)
- Longstanding Puzzle (1)
- Losing Weight (1)
- Manic Depressive Disorder (1)
- Many Young Adults (1)
- Marc Sommer (1)
- Margaret Sheridan (1)
- Massachusetts General Hospital (1)
- Media Messages (1)
- Medicine Report (1)
- Memory Task (1)
- Mental Alertness (1)
- Mental Health (10)
- Michael Sporn (1)
- Michigan State University (1)
- Mild Cognitive Impairment Mci (1)
- Molecular Energy (1)
- Molecular Screening (1)
- Mood Effects (1)
- Mood Enhancers (1)
- Mood Modulators (1)
- Mood Swings (1)
- Motivation (1)
- Motor Responses (1)
- Mount Sinai School (2)
- Mount Sinai School Of Medicine (2)
- Mouse Models (1)
- Mouse Study (1)
- Mssr (1)
- National Autonomous University (1)
- National Autonomous University Of Mexico (1)
- Negative Changes (1)
- Neurons In The Brain (1)
- Neuropsychological Tests (1)
- Northeastern University (1)
- Northwestern University (1)
- Notre Dame (1)
- Nutritional Counselors (1)
- OCD (1)
- odds (7)
- Ohio State University (3)
- Omega 3 Fatty Acids (1)
- Organizational Settings (1)
- Outlook Help (1)
- Parenting & Children (6)
- Paul Patterson (1)
- Penn State University (1)
- Personality Psychology (1)
- Pines Institute (1)
- Postdoctoral Researcher (1)
- Premorbid (1)
- Prestige (1)
- Prior Research (1)
- Prominence (1)
- Psychiatry Research (1)
- Psychological Bulletin (1)
- Psychological Science (6)
- Psychology (50)
- Psychotic Symptoms (1)
- PTSD (5)
- Quebec National Assembly (1)
- Racial Background (1)
- Receipt (1)
- Red Wine (1)
- Reducing Stress (1)
- Reflection (1)
- Repetitive Behavior (1)
- Research (85)
- Restrictive Diets (1)
- Rich Cocoa (1)
- Robert Wright (1)
- Sackler Faculty (1)
- Sadness (2)
- San Diego State University (1)
- Sanctuary (1)
- Saturday June (1)
- Scant Attention (1)
- Scarf (1)
- Scary (1)
- SCD (1)
- Scenarios (2)
- Schizophreni (1)
- Schizophrenia (10)
- Schizophrenia Patients (2)
- Schizophrenic Patient (1)
- Schizophrenic Patients (2)
- School (2)
- School Counselor (1)
- School Detention (1)
- School Of Medicine (1)
- Schwabe (2)
- science (2)
- Science And Technology (1)
- Science Source (1)
- Science Technology (1)
- Seclusion (1)
- Secret Government (1)
- Self Awareness (1)
- Self Control (1)
- Self Experience (1)
- Self Harm (2)
- self help (3)
- Self Perception (2)
- Self-esteem (9)
- Senior Adults (1)
- Senior Moments (1)
- Seniors (2)
- Sense Of Humor (1)
- Sense Of Self (1)
- Separate Entities (1)
- Separate Ways (1)
- Serani (1)
- Serious Danger (1)
- Serotonin (1)
- Severity (1)
- Sex (3)
- Sex Provider (1)
- Sex Roles (1)
- Sex Workers (1)
- Sexual Assault Victim (1)
- Sexual Encounters (1)
- Sexual selection (1)
- Shame (1)
- Sharp Edge (1)
- Shattered Dreams (1)
- Sheba Medical Center (1)
- Shlomi (1)
- Short Stories (1)
- Short Term Memory (1)
- Siberian Hamsters (1)
- Sibling Pairs (1)
- Sick Time (1)
- Sicknesses (1)
- Significant Impact (1)
- Signs Of Depression (1)
- Simulation Training (1)
- Single (music) (1)
- Single Day (1)
- Six Months (1)
- Skipping Meals (1)
- Skipping School (1)
- Sleep (8)
- Sleep Disorders (1)
- Sleep Disturbances (1)
- Sleep Loss (1)
- Sleep Patterns (1)
- Sleep Problems (1)
- Sleep Timer (1)
- Slow-Carb Diet (1)
- Smart Comments (1)
- Smoking Marijuana (1)
- Social Anxiety (1)
- Social Attachments (1)
- Social Behavior (1)
- Social Connectedness (1)
- Social Connections (1)
- Social Interactions (1)
- Social Issues (1)
- Social Ladder (1)
- Social Networking (2)
- Social Networks (1)
- Social Phobia (2)
- Social Relationships (1)
- Societal Problems (1)
- society (1)
- Society for Personality and Social Psychology (5)
- Sociologists (1)
- software-development (1)
- Sophomore (1)
- Sore Throats (1)
- Sorrow (1)
- Sounds (2)
- Spatial Abilities (1)
- Spatial Skills (1)
- Specific Foods (1)
- Spectrum Disorder (1)
- Speech Recognition Software (1)
- Spending Time With Family (1)
- Spirituality (1)
- Spite (1)
- Spontaneous Experience (1)
- Sporting Clubs (1)
- Sports Medicine (1)
- Spot The Difference (1)
- Spot The Difference Game (1)
- Stages Of Schizophrenia (1)
- Stalker (1)
- Standardized Tests (1)
- Stansbury (1)
- State Illinois (1)
- State Wisconsin (1)
- Stay At Home (1)
- Stay At Home Mom (1)
- Stay Home (1)
- Steady Source (1)
- Stem Cells (2)
- Steps (group) (1)
- Stereotype (1)
- Stereotyped Behaviors (1)
- Stevens Point (1)
- Stomach (1)
- Story Technology (1)
- Strange Face (1)
- Strange Thoughts (1)
- Stream Of Consciousness (1)
- Streetlight (1)
- Stress (17)
- Stress Changes (1)
- Stress hormone (2)
- Stress Hormones (1)
- Stress Levels (1)
- Stress Reduction (3)
- Stress Response (2)
- Stressed Individuals (1)
- Stressful Event (1)
- Stressors (1)
- Strife (1)
- Striking Similarity (1)
- Striking Variation (1)
- Stroke Prevention (2)
- Strong Woman (1)
- Strous (1)
- Structure And Function Of The Brain (1)
- Student (1)
- Student Academic Performance (1)
- Student Achievement (1)
- Student Affairs Professionals (1)
- Student Performance (1)
- Student Researchers (1)
- Students (11)
- Students Ages (2)
- Study Author (1)
- Study Findings (2)
- Study Group (1)
- Study Investigators (2)
- Study Participants (5)
- Study Researchers (9)
- Study Reveals That (1)
- Study Subjects (1)
- Study Suggests That (2)
- Study Women (1)
- Stuff (1)
- Substance abuse (4)
- Substance Use (1)
- Subtle Differences (1)
- Subtle Disturbances (1)
- Suicidal Thoughts (1)
- Suicide (5)
- Suicide Note (1)
- Suicide Risk (1)
- Suitcase (1)
- Sun Night (1)
- Supervision (1)
- Supportive Care (1)
- Susan J. Elliott (1)
- Suspicions (1)
- Suzanne Burgoyne (1)
- Sway (1)
- Sweden (1)
- Switch Languages (1)
- Sympathy (1)
- Symptoms Of Depression (2)
- Symptoms Of Post Traumatic Stress Disorder (2)
- Symptoms Of Schizophrenia (1)
- Synaptic Connections (1)
- Taking Your Mind (1)
- Talents (1)
- Tantrum (1)
- Target (1)
- Teacher Incentives (1)
- Teacher Ratings (1)
- Technological Workforce (1)
- Technology (13)
- Technology Engineering (1)
- ted (1)
- Teen Drinking (1)
- Teen Issues (4)
- Teenage Boy (1)
- Teenage Years (1)
- Teens (1)
- Tel Aviv University (1)
- Telling The Truth (1)
- Term Alcohol (1)
- Term Consequences (1)
- Term Experts (1)
- Term Goals (1)
- Text Message (1)
- Text Messages (1)
- Texts (1)
- Thanx (1)
- The Emotional Toolkit: Seven Power-Skills to Nail Your Bad Feelings (1)
- The Power of a Positive No: How to Say No and Still Get to Yes (1)
- Therapeutic Effects (1)
- Therapy? (9)
- Thinking About Things (1)
- Third Ventricle (1)
- Thomas Mussweiler (1)
- Thought (3)
- Thought Disorder (1)
- Thoughts And Feelings (1)
- Thoughts In My Head (1)
- Thousands Of Dollars (1)
- tight muscles (1)
- Tim (1)
- Time Caretaker (1)
- Time Honored Tradition (1)
- Time limit (video game terminology) (1)
- Time Researchers (1)
- Time With Family (1)
- Timer Function (1)
- Timothy Ferriss (1)
- Tissue Loss (1)
- Tnjpoetry (1)
- Today's Healthcare (4)
- Tolcapone (1)
- Tolerance Policy (1)
- Total Population (1)
- Tough Love (1)
- Tourism Management (1)
- Tracking Technology (1)
- Train Health Professionals (1)
- Train Psychologists (1)
- Training Period (1)
- Transcription Factor (1)
- Transgression (1)
- Transition From High School To College (1)
- Trauma (1)
- Traumatic Stress Disorder (4)
- travel (1)
- Treating Schizophrenia (1)
- Treatment For Post Traumatic Stress Disorder (1)
- Treatment group (1)
- Treatment Regime (1)
- Treatment Resistance (1)
- Triterpenoid (1)
- Trojan (1)
- Troubled Relationship (1)
- Tumor Necrosis Factor (1)
- Type 2 Diabetes (1)
- Typical Schedule (1)
- Uc San Diego (1)
- Ucla Researchers (2)
- Ucla Scientists (1)
- Ulsan (1)
- Unanswered Questions (1)
- Uncategorized (110)
- Uncertainty (1)
- Unclothed (1)
- Unconditioned Stimulus (1)
- Underpinnings (1)
- Undesirable Behavior (1)
- Undying Support (1)
- Unfairness (1)
- Unhealthy Behaviors (2)
- Unhealthy Food (2)
- United Kindom (1)
- United States (1)
- University Medical Center (1)
- University Of California Berkeley (1)
- University Of California Davis (1)
- University Of California Los Angeles (1)
- University Of California San Diego (2)
- University Of California San Francisco (2)
- University Of Chile (1)
- University Of Massachusetts (1)
- University of Michigan (1)
- University Of Milan (1)
- University of Notre Dame (1)
- University Of Oxford (1)
- University Of Pennsylvania (1)
- University Of Queensland (1)
- University Of Queensland Australia (1)
- University Of Science And Technology (1)
- University Of The Witwatersrand (1)
- University Of Warwick (1)
- University Researcher (1)
- University Researchers (2)
- Unreal (1)
- Unsung Heroes (1)
- Ups (2)
- Ups And Downs (1)
- Urban Area (1)
- Urge (1)
- Urges (1)
- Ury (1)
- Using Imaging (1)
- vacation (2)
- Vacations (2)
- Valproic Acid (1)
- Vandalism (1)
- Vascular Surgeon (1)
- Verbal Fluency (1)
- Verbal Memory (1)
- Vets (1)
- Vicious Cycle (1)
- Video Surveillance (1)
- Videos (1)
- Violence and Abuse (1)
- Viral Infection (1)
- Virology (1)
- Virtual Patients (1)
- Virtual Reality Laboratory (1)
- Virtual Reality Technology (1)
- Virtual Simulations (1)
- Virtues (1)
- Viruses (1)
- Visu (1)
- Visua (1)
- Visual Attention (2)
- Visual Decision (1)
- Visual Stimuli (1)
- Visual Tasks (1)
- Vital Subject (1)
- Vitamin Deficiency (1)
- Voice Directions (1)
- Volume Loss (1)
- Voluntary Effort (1)
- Vulnerability (1)
- Vulnerable Individuals (1)
- Vulnerable Times (1)
- Waist Circumference (1)
- Wansink (1)
- Wayne State University (1)
- Weather Prediction (1)
- Web Activities (1)
- Weight loss (1)
- Weight Values (1)
- Weights (1)
- Western Countries (1)
- Western Culture (1)
- Western Societies (1)
- Wh (1)
- What The Heck (1)
- White Lies (1)
- White Matter (3)
- Whole Brain (1)
- William Ury (1)
- Windowsill (1)
- Wine Drinkers (1)
- Witch (1)
- Womb (1)
- women (20)
- Work (1)
- Work and Career (23)
- Work Demonstrates That (1)
- Work Groups (1)
- Workaholic (1)
- Working Memory (3)
- Workout (1)
- Workplace Health (1)
- Worktop (1)
- World Depression (1)
- World Development (1)
- World Researchers (1)
- Worries (1)
- Worst Time (1)
- Wounds and Healing (1)
- Yale Scientists (1)
- Year 1 (1)
- Yeoman (1)
- Yoga (1)
- Yohimbine (1)
- Young Adulthood (1)
- Young Adults (2)
- Young Boys (1)
- Young Woman (1)
- Younger Boy (1)
- Younger Men (1)
- Youngsters (1)
- YourTango (1)
- Youth (1)
- Youth Group (1)
- Youth Groups (1)
- Zago (1)
- Zheng Wang (1)
- Zhou (1)
Best of ours..
must watch...
- None
get your wp….
feedburner
grab from past….
- August 2012 (68)
- July 2012 (100)
- June 2012 (36)
- January 2012 (1)
We are on google+
February 2019 M T W T F S S « Aug 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Blog Stats
- 2,318 hits
me
Blogroll